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ImmunoLin: Immune Enhancement
Your body wants to be healthy. It fights daily to keep infections and germs under control.
Stress, smoking, poor nutrition, dieting, travel, diesase, medical therapies, strenuous athletic
training and growing older all make it harder for our bodies to fight illness. We get sick more
easily and take longer to bounce back.
We take multivitamins, but it just isn't enough. Why?
The Science of Immunity - Immunoglobulins
The basic functions of immunoglobulins are the neutralization and opsonization of bacteria, viruses,
and other environmental pathogens. Neutralization means that the antibodies have bound to an antigen
and this prevents the antigen from finding its target. For example, if the antigen bound by an antibody
is a protein comprising part of a bacterium or virus, the antibody can prevent the attachment of the
bacteria or virus to the host. Likewise, binding of an antibody to a toxin prevents the uptake of the
toxin by the body. In both examples, the antibody has effectively neutralized the bacteria, virus and/or toxin.
Opsonization describes the coating of an antigen with antibodies so that it can be recognized as foreign;
ingested by specialized white blood cells; destroyed; and, presented on the surface of the white blood
cells for recognition by the other cells of the immune system. Unlike antibiotics, antibodies also allow
the immune system to specifically recognize pathogens while ignoring good bacteria that are a part of the
body's normal microflora. The proven functions of antibodies are the reason they are considered to be a
viable anti-infective strategy. (1)
| How we get sick, feel achy and run down... |
| Phase 1 |
Our body's immune system defends against infection and illness by releasing immunoglobulin (antibodies.)
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Many germs enter our bodies through ingestion. They end up in the 400 sq. feet of GI tract surface area
where immunoglobulin works to neutralize the germs.
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| Phase 2 |
But, our immune system, weakened from busy lives, stress, aging and crowded conditions doesn't have
the resources to fight germs at point of entry.
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The body, now under distress, actually releases less immunoglobulin to the GI tract as it prepares to
use its resources elsewhere.
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| Phase 3 |
Fewer antibodies decrease our ability to fight and increases our susceptibility to illness.
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The germs activate the immune system and trigger inflammatory cytokine production (IL-1, IL-6 and TNF-a.)
Cytokines break down body protein into amino acids. The liver processes the amino acids and they are lost as urea
until metabolism comes back to normal. We feel achy and run down.
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We feel bad for 5 to 7 days, or until the body can produce enough specific antibodies to fight the germs.
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Why Oral Supplementation?
The transfer of immunity through oral supplementation is a natural, logical and effective process for obtaining
immunity. First, immunoglobulin is the principal anti-infective component of breast-milk and colostrum. In
adults, the concentration of immunoglobulin in the digestive tract and on mucosal surfaces is predictive of
the risk of infection!(2,3)
Stress and many other conditions increase the risk of infection by reducing immunoglobulin secretion and
antibody production.(4,5) Oral immunoglobulin supplementation has been found to help preserve the normal protective
barrier of the digestive tract and provide humoral immunity to the gut.(6)
Immune challenge studies are very difficult and expensive to perform on humans, so many of these studies must
utilize animal models. Such studies have found that oral immuno-protein supplementation restores appetite,(7,11) reduces
inflammation,(11) and promotes improved protein metabolism(8,10) in animals experiencing immunological stress.
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| Phase 4 |
Oral supplementation of ImmunoLin immunoglobulin provides immediate support to the immune system.
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The all-natural immunoglobulin in ImmunoLin goes to work immediately to neutralize germs. Inflammatory
cytokine production is reduced. We feel better within hours! And with continued supplementation, we stay healthy
day after day!
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View this information in a printable pdf format.
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The Gut Connection to Good Health
Almost 80% of all disease and infections enter the body either through mucosal tissue or stay localized on
mucosal surfaces. Immune cells located in the digestive tract produce tremendous quantities, approximately
5 g per day, of immunoglobulin in the form of secretory IgA, which prevents and resolves infections from any
pathogenic organisms (bacteria, viruses and others) and toxins normally found in the gut.
Supplemental immunoglobulins first act in the intestinal tract to eliminate or inhibit the proliferation of
disease-causing organisms and toxins. It is this action against invading antigens in the bowel that creates
the link between the gut and the rest of the body. The inhibition of the growth of opportunistic organisms
or the absorption of toxins by the bowel reduces the stimulation of the immune system. Thus, the body's
resources, particularly amino acids, which would normally be directed towards those challenges, can be
redirected to other "battles" in other parts of the body.
Supplementation with immunoglobulins reduces the demand in the gut for naturally produced antibodies. Since
the body's resources are finite, conservation of immune resources in the gut allows more resources to be
available wherever else they may be needed.
ImmunoLin - The Immunoglobulin of Choice
Proliant has used this understanding of the immune system to develop a unique immune system to develop a unique
immune ingredient called ImmunoLin. ImmunoLin is a natural, concentrated source of immunoglobulin and other
immuno-proteins that are derived from cattle specifically raised for food. Such food animals produce specific
humoral immunity against a broad range of organisms because they are routinely exposed to common environmental
pathogens to a much greater degree than humans. As a result, immunoglobulin of bovine origin contains antibodies
that are also specific to human pathogens. This includes such pathogens as E. coli (Freedman et al., 1998;
Griffiths and Humpheys, 1977), H. pylori (Korhonen et al., 1995), cryptosporidia (Osame et al., 1991), and
rotavirus (Acres and Babiuk, 1978; Hess and Bachman, 1981; Ushijima et al., 1990). ImmunoLin® is particularly
rich in the immunoglobulins IgG, IgM and IgA. It also contains transferrin, endotoxin-binding proteins and
other acute phase proteins that can provide additional immune support benefits.
Return To ImmunoLin Main Page
References:
(1) Casadevall A. Exp. Opin. Invest Drugs 1998; 7(3): 307-21.
(2) Cantey JR. Adv. Exp. Med. Biol. 1978; 107(1):46170.
(3) Gleeson M. Int.l/Sports Med. 2000.May.; 21. Suppl. 1.:S33.-43.21.
(4) Jemmatt JB, et al. Lancer 1983 Jun 25; I (8339):1400-2.
(5) Miletic ID, et al. Physiol. Behav. 1996 Jul; 60(1):243-8.
(6) Dickinson EC, et al. Surgery 1998 Aug; 124(2):284-90.
(7) Kats U, et al. J. Anim. Sci. 1994;72:2075-81.
(8) Thomson JE et al. J. Anim. Sci. 1995;73:(2340):2346.
(9) Coffey RD, et al. J. Anim. Sci. 1995;/3:2532-9.
(10) Jiang R, et al. J. Nutr. 2000;130:21-6.
(11) Pierce JL, et al. J. Anim. Sci. 1996;171.
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